Thoughts regarding drug delivery.

BKC College

Kolkata-700108, India

Some of the latest concepts of medicinal science are indebted to Hahnemann’s intuition regarding holistic approach of cure. Patient-specific treatment, therapeutic vaccination (both involve proteomics), drug-targeting and drug-delivery technique by applying least amount of medicine within micelle and liposome as ‘carrier’, all are the latest outcome of his philosophy.

Yet, according to many scientists infinitesimally diluted drugs have no molecule of the original remedy left; they therefore are ‘non-molecular and non-functional’. There are several theories about how such a medicine can function, but all of them suffer from some shortcomings.

However, after observing some experimental evidences it has recently been suggested that diluting away of molecules is possible so long as the solution remains homogeneous. When homogeneity is lost, few molecules can be obtained up to much higher dilution than Avogadro’s limit (12C).

As water has a high Dielectric Constant (DC= 80), it can separate the +ve and -ve charges of the solute molecule wide apart, but during ritualized succession and infinitesimal dilution, where the number of solute molecules is depleting drastically, the number of solvent molecules covering its surface increases making the charged particles come close together, eventually the DC falls. Moreover, addition of ethanol (DC = 24) to such an aqueous medium causes further reduction of DC. As a result, the solute molecules become more concentrated towards the bottom of the vial and non-homogeneity is established.

If one tries to transfer a drop of such a non-homogeneous dilution to the next vial of fresh ethanol, the solute molecules gaining much higher speed than the solvent molecule become fluvial, rush to the next container, but most of them cannot return to the original vial due to loss of homogeneity.Therefore, we can make single line serial dilution one after another without reaching zero-molecular state.

Succussion between each two steps of dilution has another utility also. The deficiency of a minute unknown enzyme(s) or transcription factor(s), which remains at the interior of a cell, is the root cause of all diseases.

Crude diluted drug cannot enter there and bring symptoms to a healthy person (‘Prover’) or cure the same from patients due to cross-reaction with other biomolecules present in the body fluid and selective permeability of the cell membrane system to that medicine. Hence, a special protective molecular orientation is required.

Succussion is comparable to sonication, which is responsible for a special type of orientation of the solvent molecules. Ethanol has a small polar head and very short hydrophobic tail. In the original tincture the heads remain arranged around hydration layer of drug molecule like that of ‘inverted micelle’. During succussion and centesimal dilution, ethanol forms another protective ‘capsule’ like sheath around the micelle, keeping their tails close to the tails of the initial layer, like ‘drug-loaded liposomes’. The number of ethanol molecules in the sheath increases with potency. Hence, the ‘capsule’ becomes more compact and its penetration ability increases.

When poured upon lactose globules the ‘capsules’ stick to them and the former acts as ‘carrier’. Deficiency of a transcription factor can create difference in protein profile between healthy and diseased individual. It may cause either depletion of a known metabolic enzyme from its normal level, or accretion of a deleterious one, much downstream to the factors, causing a particular combination of symptoms in patients.

When such symptoms become similar to drug-induced symptoms of a healthy person, it indicates that the minute unknown factor in both is the same. ‘Proving’ is therefore an indirect way of identifying the factor(s). It represents blockage at the same location of branching metabolic pipelines, manifested in terms of symptoms by scanty flow of some metabolites and overflow of others. Thus, the same drug can indirectly be selected, and recovery is possible by triggering the said factor, comparable to ‘gentle hammering’ to that particular point of pipelines to remove the blockage. When the blockage ‘flows away’ towards the terminals, older symptoms would return before the final recovery.

The active principles of medicines mostly are plant products containing alkaloids, exudates of healthy or diseased tissue containing antigens, or comes from mineral kingdom.

These are actually a ligand-inhibitor of that minute unknown protein factor as they can mimic the substrate or product of the respective enzymes, or antigen of the respective antibody. When these are applied to ‘Prover’ or patients the drug loaded ‘capsules’ move in an enormous speed through the body fluid and strike the lipid bilayer of the affected cell, which undergoes ‘flip-flop transition’, so that entry of drug molecules to the interior, even up to the nucleus becomes possible. In course of journey through the lipid bilayers the protective ethanol capsules is lost and the medicine molecules directly or indirectly bind with specific transcription factor by replacing its original ligand-inducer. It causes expression of symptoms in ‘Provers’. In patients it results slight aggravation of symptoms due to additional overflow of the deleterious product or further deficiency of the useful metabolite. Lastly, there is a ‘gentle recovery’. Thus, the defective protein profile in patient might be rectified.

As the principle of homeopathy (or Isopathy) is a stimulatory one it is similar to ‘hormesis’ (the achievement of tolerance over a poison by pretreatment of the same), by which the number of competent cells increases in tissue day by day and/or the number of competent DNA segments increases in genome to overcome the induced ‘stress’ by the removal of the deleterious product or compensation of the deficient one. An autoradiographic method has been suggested to sort out the correct remedy (a ligand-inhibitor of the minute deficient factor, semantic to the deleterious product) without matching the Prover’s symptoms. Such a stimulatory method might be effective for any dynamic disease, including cancer and AIDS. Some preliminary success (rectification of protein profile of cancer patients) has been achieved very recently by following the said protocol.

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One response to “Thoughts regarding drug delivery.

  1. I don’t understand this paragraph:

    If one tries to transfer a drop of such a non-homogeneous dilution to the next vial of fresh ethanol, the solute molecules gaining much higher speed than the solvent molecule become fluvial, rush to the next container, but most of them cannot return to the original vial due to loss of homogeneity.Therefore, we can make single line serial dilution one after another without reaching zero-molecular state.

    What does he mean ” rush to the next container” and “return to the original container” and “cannot return to the orginal vial”. I don’t understand what he means. And “fluvial” is that the same as sediment transport?

    There is more I don’t understand but I’ll start with this.

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